Super-resolution Microvessel Imaging

Ultrafast imaging of contrast microbubbles in a rabbit kidney:

Microbubble localization and tracking:

Microbubble signal accumulation: super-resolution imaging (bottom) has marked resolution improvement over regular ultrasound (top).

Related publications:

  1. Gong P, Song P, Chen S*, “On Combination of Hadamard-encoded Multi-pulses (HEM) and Multiplane Wave (MW) Transmission in Contrast Enhanced Ultrasound Imaging”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 10, pp. 1970-1980, 2018PDF
  2. Song P, Manduca A, Trzasko JD, Daigle RE, Chen S*, “On the Effects of Spatial Sampling Quantization in Super-Resolution Ultrasound Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 12, pp. 2264-2276, 2018. PDF
  3. Liu X, Gong P, Song P, Xie F, Miller AL, Chen S, Lu L*, “Fast Functionalization of Ultrasound Microbubbles Using Strain Promoted Click Chemistry,” Biomaterials Science, vol. 6, issue 3, pp. 623-632, 2018.
  4. (IEEE TUFFC cover) Song P, Trzasko JD, Manduca A, Huang R, Kadirvel R, Kallmes DF, Chen S*, “Improved Super-Resolution Ultrasound Microvessel Imaging with Spatiotemporal Nonlocal Means Filtering and Bipartite Graph-Based Microbubble Tracking,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 2, pp. 149-167, 2018. PDF
  5. Gong P, Song P, Chen S*, “Improved Contrast Enhanced Ultrasound Imaging with Multiplane Wave Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 2, pp. 178-187, 2018. PDF
  6. Gong P, Song P, Chen S*, “Hadamard Encoded Multi-Pulses for Contrast Enhanced Ultrasound Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, issue 11, pp. 1674-1683, 2017. PDF
  7. Tang S†, Song P†, Trzasko JD, Manduca A, Huang C, Lowerison MR, Gong P, Lok UW, Chen S*, “Kalman Filter-Based Microbubble Tracking for Robust Super-Resolution Ultrasound Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 9, pp. 1738-1751, 2020. PDF
  8. (Media coverage by Physics World) Lowerison MR†, Huang C†, Lucien F, Chen S*, Song P*, “Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia,” Scientific Reports, 10: 2478, 2020. PDF
  9. Huang C†, Lowerison MR†, Trzasko JD, Manduca A, Bresler Y, Tang S, Gong P, Lok UW, Song P*, Chen S*, “Short Acquisition Time Super-Resolution Ultrasound Microvessel Imaging via Microbubble Separation” Scientific Reports, (10):6007, 2020. PDF
  10. Lowerison MR, Huang C, Kim Y, Lucien F, Chen S, Song P*, “In Vivo Confocal Imaging of Fluorescently Labelled Microbubbles: Implications for Ultrasound Localization Microscopy,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 9, pp. 1811-1819, 2020. PDF

Grant support:

  1. K99/R00CA214523 from the National Cancer Institute (NCI) of the National Institutes of Health (NIH).
  2. R21EB030072 Trailblazer Award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of NIH.